Whilst playing The Witcher 3 I was pretty disgusted by the Crones of Crookback Bog, not only do they eat children but the characters were designed to trigger feelings of abhorrence in the player.
From they way they moved and twitched, their highly processed voices and most especial some of the facial features.
One in particular was designed to trigger Trypophobia, a fear of holes due to thoughts of what might be lurking in them.

The Lotus seed pod is also known to trigger this is in some people and was probably used as inspiration for the character design.